Trial Summary

***** The SCIPI Trial has now closed *****

What is the study about?

The study is designed to find out whether insulin treatment using insulin pumps is more effective than insulin treatment using insulin injections in babies, children and young people who have just been diagnosed with type I diabetes.

What is insulin and how can it be given?

Insulin is a hormone (a chemical in the blood which influences body function). It is produced by the pancreas (a gland/organ in the body) and controls the amount of glucose (sugar) in our blood. We always need some insulin, and produce extra whenever we eat food that contains carbohydrate (as carbohydrates are converted into glucose and then stored in the liver by insulin). People with type I diabetes do not make enough insulin and their blood glucose levels are too high as it does not get stored away.

 

When we treat people who have type I diabetes we try to copy the normal pattern of insulin release. We can do this in two ways:-

1. Insulin pumps

We can use a small pump that injects insulin through a fine tube just under the skin. A very small amount of insulin is injected between meals and snacks. When patients eat food that contains carbohydrate they press a button on the pump to give extra insulin.  Patients are attached to the pump all the time except when they take a shower or a bath or go swimming and during some sports. They carry the pump in a pocket, attached to a belt or in a small pouch. 

2. Insulin injections

We can also give insulin using an insulin injection pen. To copy the normal levels of insulin we use two kinds of insulin. The first type of insulin is given once or twice a day. This injection gives a low level of insulin for about 24 hours. When patients eat we give a second type of insulin that works very quickly and leaves the body after a couple of hours.

How will we know which is the best treatment?

The following information will be collected and looked at to help us decide if one of the treatment is best:

-          Glucose control

-          Quality of life

-          Side effects

-          Cost effectiveness

If you want to find out more about diabetes please visit the Diabetes UK website.

  

Schematic Representation of Study Design

 

 

 




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